GLP-1 agonist side effects (e.g. nausea) greater in those with better taste & smell. Over 10% of the US population are prescribed glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to combat obesity. Although they decrease cravings for foods, their influence on chemosensory function is unknown.
Background The positive influences of glucagon-like peptide-1 (GLP-1) on blood glucose homeostasis, appetite sensations, and food intake provide a strong rationale for its therapeutic potential in the nutritional management of obesity and type 2 diabetes. Aim To summarize GLP-1 physiology and the nutritional modulation of its secretion in the context of obesity and type 2 diabetes management ...
Eating for pleasure is called hedonic eating and is driven by food palatability, or how good it tastes, rather than hunger. In short, the better a food tastes, the more people eat of it. The mechanism by which it is controlled in humans is not currently understood.
On days 1 and 90, following intake of a standardized breakfast, glucose, insulin and glucagon-like peptide 1 (GLP-1) in plasma were measured, as well as subjective ratings of hunger, satiety and urge for different palatable foods, using visual analogue scales.
The palatability of food has been proposed as being a factor that modulates this set point, and the observation that increases in the percent calories from fat of food increase caloric intake and the defense of a higher body weight support this notion.
